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In this analysis, we included the negative allosteric modulators NNC0640 (PDB: 5VEX) and PF-06372222 (PDB: 6KJV), the peptide agonists GLP-1 (7-36) (PDB: 6X18), exenatide (PDB: 7LLL) and semaglutide (PDB: 7KI0) as well as the small molecule agonist danuglipron (PDB: 6X1A) (Supplementary Data 1)

The implications are significant, McDonald said, as researchers look at early evidence that these weight-loss drugs could help prevent new cases, slow disease progression, increase survival rates and prevent cancer recurrence not just for breast cancer, but for many other cancers

Bie J, Pruszyska-Oszmaek E, Koodziejski P, Leciejewska N, Szczepankiewicz D, Sassek M

The company is involved in diabetes treatment through GLP-1 receptor agonists and combination therapies