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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin

In preclinical research settings, experimental models may examine its role in pathways associated with oxidative stress regulation, detoxification mechanisms, and cellular response systems

It detoxifies xenobiotics and heavy metals through a reaction catalyzed by GSH S-transferases that bind them to the sulfhydryl group on the cysteine residue