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Detection and clearance of damaged lysosomes by the endo-lysosomal damage response and lysophagy

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If it is almost time for your next scheduled dose, skip the missed dose and inject on your regular day

For now, we will simply observe that if electron transport is inhibited for some reason, yet the NADH/NAD + ratio remains significantly elevated above its equilibrium mass action ratio, then electrons may leave the electron transport chain and move onto O 2 to create O 2 .- Other physiologic changes in mitochondria may also increase ROS generation without necessarily dramatically affecting oxidative phosphorylation