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-fetoprotein (AFP), an extensively used tumor marker in clinical practice, is not an appropriate biomarker for hepatocellular carcinoma diagnosis, on account of its low sensitivity and poor specificity

It does not provide dosing advice, dose-change recommendations, or missed-dose medical instructions

Data limitations: No completed human efficacy trial exists for any indication, and the literatures short observation windows mean long-term safety in either animals or humans remains unestablished

They were designed by different companies to do overlapping jobs through different biology, and the evidence behind each sits at a different tier