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Future studies need to focus on identifying the molecular mechanisms associated with gut microbiota that mediate these effects, exploring their potential as immunomodulatory therapeutics in high-altitude environments

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Besides serving as energy substrates, free glutamine and glutamate are both specific precursors for glutathione, which is the main antioxidant in IECs and immune cells and critical for the prevention of cellular damage caused by pro-oxidants (94)

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