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Wu J, Vodovotz Y, Abdelhamid S, Guyette FX, Yaffe MB, Gruen DS, et al

Researchers continue to study how its biological activity influences epithelial tissues, tendons, ligaments, and other connective tissues while expanding scientific understanding of the cellular mechanisms that regulate tissue integrity and adaptation

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These findings are further corroborated by experimental models that show increased NOX4 activity under oxidative stress conditions, including treatment with RAS-selective lethal small molecule 3 (RSL3) or erastin, which have been shown to enhance lipid peroxidation and subsequent cell death (111,112)