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Medium was changed containing different concentrations of CuCl 2 or CuSO 4 (0, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2mmol/l)

It upregulates vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), stimulates angiogenesis to improve blood supply to damaged tissue, and enhances collagen synthesis at injury sites

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In the future, however, considering that the same metabolic target may exert opposite effects on tumors and immune cells, careful evaluation of the net outcome will be essential