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In China, public and clinical awareness of GLP-1 therapies for overweight and obesity had emerged prior to the approval of Wegovy and Mounjaro and was further strengthened following the drugs mid-2024 approvals for chronic weight management

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"Instead, it has remained remarkably robust, raising important questions about how these products are regulated and how patients can know whether they're receiving medications that meet appropriate quality standards." Compounded GLP-1 drugs expanded rapidly during nationwide shortages of Wegovy and Zepbound, when federal regulations temporarily allowed pharmacies to compound copies of medications in short supply

Nonetheless, reduced side effects at lower doses make it likely there are also reduced therapeutic effects