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Via AMPK/SIRT1/PGC-1 signaling, they promote mitochondrial biogenesis (6668) and enhance PINK1- and Parkin-mediated mitophagy

The GLP1R/GIPR dual agonist NNC 00902746 (Novo Nordisk) significantly improved hemoglobin A1c (A1c) in T2DM (a reduction of 0.96% vs placebo) over a 12-week period, accompanied by a reduction in body weight