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As such, it is pertinent to consider or add anti-obesity medications as adjunct to lifestyle therapy in people with weight-related complications (including uncontrolled diabetes), those who have difficulties losing weight with lifestyle therapy, or who have experienced weight regain following initial success on lifestyle therapy alone [19]

In addition to trying to preserve muscle mass, new weight-loss drugs are also looking to avoid the gastrointestinal (GI) side effects that can come with GLP-1s

Tirzepatides added structural complexity likely makes the same issue harder to get around

IV NAD+ is delivered slowly over 2-4 hours