Common indicators include: Elevated homocysteine levels (above 10-15 mol/L) Chronic fatigue and low energy Anxiety, depression, or brain fog Hormonal imbalances (PMS, infertility, irregular periods) Recurrent miscarriages or pregnancy complications Cardiovascular issues (high blood pressure, blood clots) Digestive problems (IBS, bloating, food sensitivities) Chronic inflammation or autoimmune conditions Many people discover they have an MTHFR mutation after experiencing unexplained health issues or through genetic testing ordered by their healthcare provider
However, granulosa cells in the ovaries of EMs patients appear abnormal and may be an important contributor to infertility
or at least not an answer to the specific question that the inquirer truly intended
Obviously, today, that is less necessary, because there's less fragmentation given all the mergers that have happened, but the PBMs still establish themselves as a key immovable piece of this puzzle