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Many previous studies have reported that the GSK3 gene is over-activated in PCOS patients ( 6.1.1.3 Phosphatase and tension homologue PTEN acts as a negative regulator: it can convert PIP3 back into PIP2, thereby inhibiting activation of the PI3K/Akt pathway ( 6.1.1.4 Lymphocyte adaptor protein Many studies have confirmed that LNK (SH2B3) is a regulatory factor in insulin signaling via its effect on glucose uptake