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Other putative mechanisms of action of GLP-1 RAs on vascular smooth muscles may include intracellular alterations in activities of protein kinase C, Rho-Kinase, myosin light chain kinase, as well as calcium handling, G-proteins, and ion channels (Lanza et al., 2011)
Eluxadoline was well tolerated in Phase 2 and Phase 3 trials, with constipation and nausea being the most common adverse effects
& Jacinto, A
Given that retatrutide remains an investigational medicine, access is currently limited to clinical trial participants
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