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While subpockets B and C are rather large, subpocket A is narrow and restricted in depth by FAD at the bottom of the pocket, limiting the choice of modifications of the inhibitor in subpocket A

10.1073/pnas.0407076101 Proc Natl Acad Sci U S A

This activity in general ECs gives rise to complex cellular communication via various ligands interacting with a single receptor, but activated through different pathways (Paik et al., 2004)