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Pharmacokinetic, pharmacodynamic, and pharmacogenetic assays to monitor clopidogrel therapy

In fact, the increased expression of glycolytic enzymes, such as HK2, which catalyze the first step in glucose metabolism, PFKFB, which plays a critical role in regulating glycolysis in the cytoplasm, and PDK1, a key enzyme that acts between glycolysis and tricarboxylic acid (TCA) cycle, supporting the idea that increased glycolysis could induce a more aggressive FLS phenotype 17,21,22,23

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Individual patient characteristics also play crucial roles