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Stress management techniques warrant consideration, as chronic stress activates the hypothalamic-pituitary-adrenal axis and can increase cortisol levels, which may intensify food cravings, particularly for high-calorie comfort foods

Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig

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