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Clinical studies specifically monitoring glucose metabolism through oral glucose tolerance tests found no significant changes in glucose handling, and fasting insulin levels remained stable throughout treatment periods lasting up to 24 weeks

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Stier, Vos, and Kenley later summarized the clinical program as comprising six randomized, double-blind, placebo-controlled trials, spanning intravenous and oral pilot studies and oral Phase IIb studies [7]

How semaglutide works as a GLP-1 receptor agonist Semaglutide is a synthetic analogue of human glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the gut after eating