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The most frequently reported adverse effects are gastrointestinal in nature and typically occur during the initial weeks of treatment or following dose increases

3 meals daily at 500-700 calories each 41% nausea rate Food sits in stomach for hours Evening nausea peaks after dinner Higher discontinuation rates 5-6 meals daily at 200-300 calories each 22% nausea rate Stomach empties between meals More stable energy levels Better overall tolerance I spent my first three weeks trying to maintain normal eating patterns

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In addition, senescence-associated secreted factors, such as interleukin 6 (IL-6), interleukin 8 (IL-8), also displayed similar expression profiles, particularly in Cys 2 -starved and erastin-treated cells (Fig