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In SUSTAIN 6 and PIONEER 6, both powered to demonstrate noninferiority (upper 95% confidence interval [CI] of the hazard ratio [HR] 7% and at high risk of CV events, defined as: i) aged 50 years with established CVD (previous CV, cerebrovascular, or peripheral vascular disease), chronic heart failure (HF) (New York Heart Association [NYHA] class II or III), or chronic kidney disease (CKD) stage 3

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Three markers of oxidative stress in diabetic retinopathy were markedly lower in the treated cells: levels of apoptosis (a form of cell death) decreased from approximately 50% in untreated cells to about 10% in semaglutide-treated cells

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