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While the development of glucagon-like peptide-1 receptor agonists (GLP-1RAs) has expanded diabetes care, the bulk of the literature on these medications derives from tightly controlled clinical trials (e.g., Phase III trials such as the global PIONEER program), with only a few studies investigating their real-world effectiveness

Glezer, L

This was a proof-of-principle that senescent cell clearance could restore organismal homeostasis

Tirzepatide : Marketed as Mounjaro (diabetes) and Zepbound (obesity), tirzepatide combines GLP-1 and GIP receptor agonism, achieving up to 22% weight loss , the highest among approved drugs