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The next sections discuss what these trials reveal about mechanism: the time course of benefit, the imaging signature of plaque stabilization, and the limits of inference from each trial design

5.0 mg/mL mix (concentrated, smaller draws) Vial size 5 mg BAC water 1.0 mL 0.25 mg 0.05 mL (5 u) 0.5 mg 0.10 mL (10 u) 1.0 mg 0.20 mL (20 u) 1.7 mg 0.34 mL (34 u) 2.4 mg 0.48 mL (48 u) Vial size 10 mg BAC water 2.0 mL 0.25 mg 0.05 mL (5 u) 0.5 mg 0.10 mL (10 u) 1.0 mg 0.20 mL (20 u) 1.7 mg 0.34 mL (34 u) 2.4 mg 0.48 mL (48 u) Concentrated mixes need more precise syringe handling, especially at the 0.25 mg starter dose

In patients with type 2 diabetes mellitus, RYBELSUS produced clinically significant reduction from baseline in HbA1c compared with placebo