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In the ECHO RCT [133], almost half of the subjects treated with weekly exenatide had a favorable treatment response with a reduction of BMI, while the other half did not respond to treatment, thus illustrating the need for an approach to address treatment nonresponse and to stratify patients with respect to predicted treatment response, using more potent GLP-1RAs and considering the use of GLP-1RAs in combination with other pharmacological approaches to treat HO