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Increased NFB activation in atherosclerosis susceptible areas leads to endothelial cell activation (Figure 1), as evidenced by increased expression of monocyte adherence proteins (VCAM-1, ICAM-1, and P-selectin) and proinflammatory receptors (toll-like receptor 2, TLR2) and cytokines (MCP-1 and IL-8) (19,23,24)

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Patients with longstanding diabetes (over 10 years) or poor prior glycemic control should undergo comprehensive dilated eye examination before starting GLP-1 medications to establish baseline retinal status

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