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Chronic low-grade inflammation in obesity and T2DM is largely sustained by an imbalance in adipose-resident immune cell populationsnotably an excess of pro-inflammatory M1 macrophages, infiltrating macrophages, and other innate immune effectorswhich disrupt insulin signaling and promote lipotoxic stress [12,50]

Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine , vol

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