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Interestingly, other studies have inhibited TGF receptor kinase activity, which reduced SMAD3 activity, and observed elevated claudin-5 expression

However, DOPAL can be detoxified by NAD(P) + -dependent aldehyde dehydrogenase (ALDH) or reduced by aldehyde/aldose reductase (ALR/AR) to form the inactive 3,4-dihydroxyphenylethanol, or further oxidized to non-toxic 3,4-dihydroxyphenylacetic acid where the aldehyde moiety is replaced by a carboxyl group [32]

The impact of NSAIDs on intestinal permeability is reinforced by the estimated 6080% of individuals using these drugs who display a disrupted gut barrier

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