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Crucially, wild-type MZB are known to be prone to activation compared to FoB 7,8,75 , and we found that both Gclc fl/fl Mb1-Cre + FoB and B6 MZB showed a similar increase in mitochondrial mass (Fig

The ATF4-mediated upregulation of amino acid transporters and one-carbon metabolism, including SLC1A1, SLC7A8 , and SHMT2 , presumably increases the supply of glutamate, cysteine, and glycine, which might act in concert for the biosynthesis of GSH