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Each member of the treatment groups in the scopolamine studies received an icv injection of scopolamine hydrobromide (70 nmol in 2 aCSF over a duration of 20 s) 30 min prior to testing followed by Dihexa 10 min prior to testing

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While this is a necessary first step, it frequently creates highly reactive, electrophilic intermediate metabolites that are actually more toxic and dangerous than the original parent compound