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(102) demonstrated that pretreatment with Ex-4 for a week, induced tolerance to cerebral ischemia that lasted for at least 6 days in the mouse brain after MCAO and this neuroprotective state was related to upregulation of IGF-1R which was mediated by GLP-1R and, following by activation of the IGF1R-regulated the PI3K/AKT/mTOR/HIF-1 pathway by binding to IGF-1

Chang, Chung-Hsun et al

In the nucleus, Nrf2 induces the expression of cytoprotective genes that mitigate ferroptosis by regulating iron metabolism and enhancing antioxidant defenses

***SPLIT***As a dietary supplement, take one (1) capsule 2 times daily with or without meals