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Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation

doi: 10.1034/j.1600-079X.2003.00040.x 46 TildenARBeckerMAAmmaLLArciniegaJMcGawAK