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One of your brains primary means of defense is its detoxification system, which eliminates toxic metabolites and oxidants
While all previous studies of amantadine as an antidyskinetic agent tested its symptomatic effect in PD patients who had established LIDs, the PREMANDYSK trial assessed if early adjunct therapy with amantadine has the potential to reduce dyskinesia risk in levodopa-treated early PD patients without LIDs [135]
Thus, bariatric surgery-induced upregulation of thiamine-dependent metabolism in jejunum (Figures 4B, 5B) may manifest metabolic remodeling addressing insufficient levels of thiamine in post-bypass enterocytes
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