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However, certain factors may prevent successful treatment, these include but are not limited to: choosing the wrong patients for the procedure, presence of large fibroids, inability to perform the procedure on the uterine arteries, not fully completing the artery blocking process, arteries spasms leading to poor embolic material flow, and the presence of additional arteries supplying blood to the uterus among others

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In addition, PDGFR/ amplification, overexpression, and constitutive activation contribute to anti-IGF-IR mAb resistance [179, 180]