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Using preclinical models, a causal link between GSH levels in the nucleus accumbens and performance was established, showing that both local and systemic modulation of GSH can influence motivated performance and stamina (17)

WT BMmacs stimulated with LPS plus IFN- for 24 hours had decreased oxygen consumption rate (OCR) but increased extracellular acidification rate (ECAR) (Supplemental Figure 11, A and B), whereas WT BMmacs stimulated with IL-4 for 24 hours displayed both increased OCR and increased ECAR (Supplemental Figure 11, C and D)

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Metformin treatment in vitro showed some impact on CD4 T cell proliferation