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Mechanistically, ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4) promotes the release of labile iron in granulosa cells, enhancing lipid peroxidation via the Fenton reaction and facilitating ferroptosis

301.1 What anchor correlation value should I use when deriving Meaningful Within Patient Change (MWPC) values Alexander Hind 1 , Mike Greenwood 1 , Kim Cocks 1 1 Adelphi Values, Manchester, UK Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :301.1 Aims Anchor-based analyses are routinely used to derive MWPC thresholds for Clinical Outcome Assessments (COAs) for use in clinical trials