Weight loss and improved insulin sensitivity reduce hyperinsulinemia and increase SHBG, thereby lowering free androgen exposure and decreasing ovarian and adrenal androgen production
Providers who work with body composition programs often notice that patients who plateau on diet and exercise alone, despite a normal-looking physique, are the ones who tend to have disproportionately high visceral fat relative to their subcutaneous fat, which is exactly the pattern Tesamorelin was designed to address
Other options, including GLP-1 based peptides like Retatrutide, reduce visceral fat as part of broader weight loss, while BPC-157 supports tissue repair rather than fat metabolism
Just under three years ago, the Food and Drug Administration deemed 19 peptide drugs too unsafe to be dispensed by compounding pharmacies, which mix components of approved drugs to create bespoke medication for people who have trouble taking commonly available products