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Initial concerns regarding pancreatitis and gastrointestinal side effects have been mitigated through extensive clinical trials, which indicate a generally favorable risk-benefit ratio

Patients should receive concurrent lifestyle counseling emphasizing nutrition, physical activity, and behavioral strategies to optimize outcomes and maintain weight loss long-term

The outcome is a daily GLP-1 pill capable of suppressing appetite and improving metabolic markers without requiring injection

This review aims to summarize the findings from CVOTs of GLP-1RAs, explore the latest data on dual and tri-agonist therapies, and delve into potential mechanisms contributing to their cardioprotective effects