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[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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245 Numerous clinical studies, both in healthy populations and in those with cardiometabolic diseases, have demonstrated the benefits of green coffee extract on lipid levels, as well as other cardiometabolic markers