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doi: 10.1007/s12020-018-1813-z 14 CostantineM

Key characteristics: A short fragment (approximately 1517 amino acids depending on the exact modification) rather than a full-length hormone Referenced in literature exploring structure-activity relationships within specific growth hormone fragments Distinct in origin and mechanism of interest from full-length growth hormone or GHRH analogues such as tesamorelin Structural Comparison Table Why Researchers Distinguish Between Them Despite both being short peptides sometimes discussed in metabolic research contexts, MOTS-C and AOD9604 have entirely different biological origins and mechanisms of research interest

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doi: 10.3389/frabi.2026.1767028 Received 13 December 2025 Revised 23 January 2026 Accepted 27 January 2026 Published 24 February 2026 Volume 5 - 2026 Edited by Manuel Gerardo Ballesteros Monrreal, University of Sonora, Mexico Reviewed by Anjna Kumari, Panjab University, India Madalina Adriana Bordea, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Updates Copyright 2026 Debta, Sahu, Patra, Debta, Mishra and Panda