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These groundbreaking findings sparked international interest in the peptides applications for longevity and age-related disease prevention

10.3389/fphys.2021.745296 Front Physiol

Kinoshita A, Nakayama Y, Kitayama T, Tomita M

This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion ( Emerging evidence further indicates that SFN promotes the repolarization of tumor-associated macrophages from the protumoral M2 phenotype toward the antitumoral M1 state