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As broad guidelines, monthly out-of-pocket costs for brand-name GLP-1 medications fall roughly in the following ranges: Ozempic : typically $250 to $400, depending on dose Rybelsus : typically $250 to $300 Wegovy : typically $400 to $600 Mounjaro and Zepbound : Following Eli Lillys December 2025 price reduction, between around $300 to $540 depending on dose Generic Semaglutide (Ozempic): Could be more than 50% cheaper than branded Ozempic, depending on how many manufacturers enter the market These are list-price estimates only