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The role of CHAC1 in apoptosis is highlighted by its function as a pro-apoptotic factor that can deplete intracellular GSH levels, reducing the cells ability to counteract ROS and oxidative stress, thereby promoting apoptotic cell death
doi: 10.1016/j.sajb.2009.10.007 79 YangJ.DuanG.LiC.LiuL.HanG.ZhangY.et al
Psoriasis is another common cause of darkening in this area, as is contact dermatitis, which can be caused by an allergy to a product or material coming into contact with the skin
Glutathione has been shown to have a positive effect on the skin, neutralising the free radicals and enhancing the cell repair mechanism, and balancing the melanin production
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