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One critical enzyme induced by Nrf2 is NAD(P)H quinone oxidoreductase-1 (NQO1), which detoxifies protein-bound quinone and maintains alpha-tocopherol and coenzyme Q10 in their reduced (antioxidant) states

Transfer of B cells expressing STAT3 to Rag1 / mice leads to enhanced tumor growth accompanied with increased angiogenesis

A better understanding of GLP-1R pleiotropic signalling and the underlying physiological consequences might provide new avenues for the development of drugs with novel modes of action that have the potential to provide greater therapeutic value while possibly avoiding unwanted side effects 12,13

The date to watch now is the Q1 2027 BLA submission