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IGF-1 is the primary mediator of HGH's anabolic effects , but unlike HGH which must first be converted by the liver into IGF-1 IGF-1 LR3 acts directly on skeletal muscle , promoting: Satellite cell activation Muscle fiber hypertrophy Accelerated tissue repair Increased glucose and amino acid uptake What makes LR3 unique is its low affinity for IGF-binding proteins (IGFBPs) , which typically limit the action of natural IGF-1