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However, treatments based on splitting alone have struggled to produce clinically meaningful outcomes

Nevertheless, according to (Sithole et al., 2025) if delivered in high concentrations, the membranes polyunsaturated fatty acids make the sperm to be very vulnerable to reactive oxygen species (ROS), resulting in lipid peroxidation (see Figure 3 )

PLA2G6 participates in phospholipid remodeling (the Lands cycle) by synthesizing new phospholipids, altering membrane phospholipid composition and thus membrane fluidity and stability, which in turn affects ferroptosis sensitivity (162)