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Additionally, genetic variants in the phosphodiesterase 8B ( PDE8B ) gene, which encodes a high-affinity cAMP-specific phosphodiesterase, as genetic modulators of TSH levels (30, 31), and in the TSH receptor (32) may also influence the setpoint of the HPT axis, potentially contributing to diminished cellular responsiveness to circulating thyroid hormones

Combining traditional forms of treatment, mainly pharmacotherapy for conditions, with normalization of the intestinal barrier and the state of microbiota can greatly enhance the efficacy and effectiveness of many therapies

2015 Jul;91(7):555-61

The presence of the hydroxyl group classifies it as a hydroxy acid, specifically a -hydroxy acid, which plays a significant role in its function as a carrier molecule for fatty acids