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5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins ( 2+ exists in the form of a labile iron pool and binds to low molecular weight compounds such as GSH ( To reduce intracellular Fe 3+ levels and prevent its conversion to Fe 2+ , iron chelators are widely employed
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Furthermore, prolonged activation of this pathway may result in neuronal loss especially in CA1 neurons and the propagation of epileptic seizures (Lopez de Armentia et al
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