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Glutathione neutralizes these radicals, but frequent exposure can drain its supply

Walsh and colleagues suggested that human plasma contains pro-survival factors as it has the capacity to inhibit erythrocytic PS exposure induced by the apoptosis inducer BH3-mimetics ( The Dynamics of PS Exposure Over Time Although induction of PS exposure in nucleated cells occurs in a matter of minutes ( Eryptosis Inducers Do Not Induce Eryptosis of Nave or Plasmodium -Infected Erythrocytes We selected six eryptosis inducers (amiodarone, BAY 43-9006, cordycepin, oridonin, benzethonium, apigenin) based on their use (or prospective use) in the clinic, their known molecular targets and/or their previously demonstrated antimalarial effects

b , Representative bright field images of Huh7 cells treated with vehicle and indicated inhibitors for 72 h

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