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Taking vitamin B12 along with vitamin C can reduce the amount of vitamin B12 available in the body

Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12

Maillet D, Corbaux P, and Stelmes JJ, et al (2020) Association between immune-related adverse events and long-term survival outcomes in patients treated with immune checkpoint inhibitors Eur J Cancer 132 6170 PMID: 32334337 21

Some people have also reported nausea, bloating, and abdominal discomfort after taking higher doses