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In addition to cardiovascular benefits, post-hoc analyses of trial data suggested that GLP-1RAs may confer renal protection, as clinical trials have consistently reported reductions in composite renal outcomes [5]

11,12 Peripherally, amylin acts as an anorectic hormone by delaying gastric emptying and suppressing glucagon secretion to attenuate a postprandial increase in blood glucose

Subsequent studies have further revealed multiple physiological roles for GLP-1R, including its key role in glycemic control

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