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For test subjects on a 2,000 g/week dosing schedule, this would equate to five 400 g injections per week or twice-daily 200 g doses

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Interestingly pharmacologically combined therapy of vit B1, B6 and B12 did not augur well in diabetics having diabetic nephropathy and substantial adverse outcomes associated with high dose vitamin B6, B9 and B12 co-supplementation in patients with advanced diabetic nephropathy was brought to light Recently concluded Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINE) study produced an unexpected accelerated decline in renal function