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29 However, subsequent studies in severely obese animal models have suggested a smaller synergistic effect in advanced leptin resistance

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Minimal Hormonal Interference IGF-1 LR3 does not: Suppress natural sex hormone production Aromatize into estrogen Convert to dihydrotestosterone (DHT) Interfere with the HPG (hypothalamus-pituitary-gonadal) axis In other words, it supports growth and repair without throwing your endocrine system off balance